| LEC # | TOPICS | READINGS |
|---|---|---|
| 1 | Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials Biodegradable Polymeric Solids Chemistry and Physical Chemistry of Hydrolysis Links between Materials Structure and Hydrolysis Mechanisms | |
| 2 | Biodegradable Polymeric Solids (cont.) Factors Controlling Polymer Degradation Rates Theory of Solid Polymer Erosion Tailoring Degradable Polymer Structure and Composition | von Burkersroda, F., L. Schedl, and A. Gopferich. "Why Degradable Polymers Undergo Surface Erosion or Bulk Erosion." Biomaterials 23, no. 21 (November 2002): 4221-4231. Supplementary Readings
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| 3 | Controlled Release Devices Types of Controlled Release Devices Degradable Materials in Controlled Release Devices Physical Chemistry Principles in Delivering Small Molecules vs. Proteins | Saltzman, W. Mark, and W. L. Olbricht. "Building Drug Delivery into Tissue Engineering." Nat Rev Drug Discov 1, no. 3 (March 2002): 177-186.
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| 4 | Controlled Release Devices (cont.) Theory of Drug Release in Eroding Systems | Charlier, A., B. Leclerc, and G. Couarraze. "Release of Mifepristone from Biodegradable Matrices: Experimental and Theoretical Evaluations." Int J Pharm 200, no. 1 (April 25, 2000): 115-20. |
| 5 | Case Studies in Complex Controlled Release Pulsatile Release from Programmed Eroding Systems Controlled Release Microchips Combining Drug Delivery with Tissue Engineering | Santini, J. T., Jr., A. C. Richards, R. Scheidt, M. J. Cima, and R. Langer. "Microchips as Controlled Drug-Delivery Devices." Angew Chem Int Ed Engl 39, no. 14 (July 17, 2000): 2396-2407. |
| 6 | Hydrogels as Biomaterials Hydrogel Structure and Physical Chemistry Methods of Polymerization | Peppas, N. A., Y. Huang, M. Torres-Lugo, J. H. Ward, and J. Zhang. "Physicochemical Foundations and Structural Design of Hydrogels in Medicine and Biology." Annu Rev Biomed Eng 2 (2000): 9-29. |
| 7 | Hydrogels as Biomaterials (cont.) Theory of Hydrogel Swelling Physical Hydrogels
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Supplementary Readings
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| 8 | Hydrogels as Biomaterials (cont.) Polyelectrolyte Hydrogels Coacervates Polyelectrolyte Multi-layers | Ron, E. S., and L. E. Bromberg. "Temperature-responsive Gels and Thermogelling Polymer Matrices for Protein and Peptide Delivery." Adv Drug Deliv Rev 31 no. 3 (May 4, 1998): 197-221. Chandler, D. "Interfaces and the Driving Force of Hydrophobic Assembly." Nature 437, no. 7059 (September 29, 2005): 640-647. |
| 9 | Hydrogels as Biomaterials (cont.) Theory of Polyelectrolyte Gel Swelling | De, S. K., N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore. "Equilibrium Swelling and Kinetics of pH-responsive Hydrogels: Models, Experiments, and Simulations." Journal of Microelectromechanical Systems 11, no. 5 (October 2002): 544-555. |
| 10 | Hydrogels as Biomaterials (cont.) Applications of Hydrogels: Molecular Imprinting Applications of Hydrogels: Glucose-sensitive Drug Delivery Kinetics of Drug Diffusion through Hydrogels | Supplementary Readings Lustig, Steven R., and Nikolaos A. Peppas. "Solute Diffusion in Swollen Membranes. IX. Scaling Laws for Solute Diffusion in Gels." Journal of Applied Polymer Science 36, no. 4 (August 5, 1988): 735-747. Canal, T., and N. A. Peppas. "Correlation between Mesh Size and Equilibrium Degree of Swelling of Polymeric Networks." J Biomed Mater Res 23, no. 10 (October 1989): 1183-1193. |
| 11 | Engineering Biological Recognition of Biomaterials Biological Recognition in Vivo Protein-resistant and Cell-resistant Surfaces Engineering Recognition of Biomaterials: Adhesion and Migration | Hirano, Y., and D. J. Mooney. "Peptide and Protein Presenting Materials for Tissue Engineering." Advanced Materials 16, no. 1, (January 2004): 17-25. Discher, D. E., P. Janmey, and Y. L. Wang. "Tissue Cells Feel and Respond to the Stiffness of their Substrate." Science 310, no. 5751 (November 18, 2005): 1139-1143. Supplementary Readings
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| Exam 1 | ||
| 12 | Engineering Biological Recognition of Biomaterials (cont.) Enzymatic Recognition of Biomaterials Cytokine Signaling from Biomaterials | Schense, J. C., J. Bloch, P. Aebischer, and J. A. Hubbell. "Enzymatic Incorporation of Bioactive Peptides into Fibrin Matrices Enhances Neurite Extension." Nat Biotechnol 18, no. 4 (April 2000): 415-419. |
| 13 | Engineering Biological Recognition of Biomaterials (cont.) Mimicking Cell-cell Contacts with Surfaces | |
| 14 | Bioceramics and Biocomposites Introduction to Biological Approaches to Biomineralization Interfacial Biomineralization |  Mann, Stephen. Biomineralization: Principles and Concepts in Bioinorganic Materials Chemistry. New York, NY: Oxford University Press, 2002, chapter 3, pp. 24-37. ISBN: 9780198508823. |
| 15 | Bioceramics and Biocomposites (cont.) Biological Control of Mineralization within Vesicles Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches |
Supplementary Readings
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| 16 | Bioceramics and Biocomposites (cont.) Theory of Controlled Nucleation Bone Structure and Bone Biomimesis Biocomposites in Device Applications and Drug Delivery | Vogel, Viola. "Reverse Engineering: Learning from Proteins How to Enhance the Performance of Synthetic Nanosystems." MRS Bulletin 27, no. 12 (December 2002): 972-978. |
| 17 | Molecular Devices Molecular Switches via Proteins and 'Smart' Polymers
Molecular motors
| Hammer, Daniel A., and Dennis E. Discher. "Synthetic Cells-Self-Assembling Polymer Membranes and Bioadhesive Colloids." Annual Review of Materials Research 31 (August 2001): 387-404. Allen T. M., and P. R Cullis. "Drug Delivery Systems: Entering the Mainstream." Science 303, no. 5665 (March 19, 2004): 1818-1822. |
| 18 | Nanoparticle and Microparticle Biomolecule Drug Carriers Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles Delivery of Drugs to Tissues via Systemic Circulation Materials for Anti-cancer Drug Delivery | Stolnik, S., L. Illum, and S. S. Davis. "Long Circulating Microparticulate Drug Carriers." Advanced Drug Delivery Reviews 16, no. 2 (September 1995): 195-214 (20). Supplementary Readings Halperin, A. "Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters." Langmuir 15, no. 7 (1999): 2525-2533. Efremova, Nadezhda V., Bruce Bondurant, David F. O'Brien, and Deborah E. Leckband. "Measurements of Interbilayer Forces and Protein Adsorption on Uncharged Lipid Bilayers Displaying Poly(ethylene glycol) Chains." Biochemistry 39 no. 12 (2000): 3441-3451. |
| 19 | Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.) Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues 'Stealth' Particles - Theory of Protein-resistant Particles Experimental Function of Long-circulating Carriers and PEGylated Compounds |
Abbas, Abul K., Andrew H. Lichtman, and Jordan S. Pober. "General Properties of Immune Responses." In Cellular and Molecular Immunology. 4th ed. Philadelphia, PA: W.B. Saunders Company, 2000. pp. 3-16. ISBN: 07216823323. |
| Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines | ||
| 20 | Basic Biology of Vaccination and Viral Infections Rudiments of Adaptive Immunity: The Basis of Vaccination Viral Infections | Raychaudhuri, S., and K. L. Rock. "Fully Mobilizing Host Defense: Building Better Vaccines." Nat Biotechnol 16, no. 11 (November 1998): 1025-1031. |
| 21 | Basic Biology of Vaccination and Viral Infections (cont.) Vaccination Against Viruses: Parallels between Immunization and Infection | Wang, C., Q. Ge, D. Ting, D. Nguyen, H. R. Shen, J. Chen, H. N. Eisen, J. Heller, R. Langer, and D. Putnam. "Molecularly Engineered Poly (ortho ester) Microspheres for Enhanced Delivery of DNA Vaccines." Nat Mater 3, no. 3 (March 2004): 190-196. (Epub: February 15, 2004). |
| 22 | Drug Targeting and Intracellular Drug Delivery for Vaccines Targeting Nano-carriers and Micro-carriers to Specific Cell Types Chemistry of Antibodies for Targeting Pathways of Intracellular Transport | Pack, D. W., A. S. Hoffman, S. Pun, and P. S. Stayton. "Design and Development of Polymers for Gene Delivery." Nat Rev Drug Discov 4, no. 7 (July 2005): 581-593. |
| 23 | Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.) Mechanisms of Intracellular Delivery Mimicking Viral Entry Strategies | Carter, P. "Improving the Efficacy of Antibody-based Cancer Therapies." Nat Rev Cancer 1, no. 2 (November 2001): 118-129. |
| 24 | DNA Vaccines Gene Therapy and DNA Immunization Mechanisms of DNA Vaccines | |
| 25 | DNA Vaccines (cont.) Delivery Systems for DNA Systemic vs. Local Delivery | |
Table of Contents
Study Materials
Readings
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