| LEC # | TOPICS | KEY DATES |
|---|---|---|
| 1 | Overview of Course, Orientation to Current Approaches and Types of Molecularly-designed Biomaterials Biodegradable Polymeric Solids Chemistry and Physical Chemistry of Hydrolysis Links between Materials Structure and Hydrolysis Mechanisms | |
| 2 | Biodegradable Polymeric Solids (cont.) Factors Controlling Polymer Degradation Rates Theory of Solid Polymer Erosion Tailoring Degradable Polymer Structure and Composition | Problem set 1 out |
| 3 | Controlled Release Devices Types of Controlled Release Devices Degradable Materials in Controlled Release Devices Physical Chemistry Principles in Delivering Small Molecules vs. Proteins | |
| 4 | Controlled Release Devices (cont.) Theory of Drug Release in Eroding Systems | Problem set 1 due Problem set 2 out |
| 5 | Case Studies in Complex Controlled Release Pulsatile Release from Programmed Eroding Systems Controlled Release Microchips Combining Drug Delivery with Tissue Engineering | Problem set 2 due Problem set 3 out |
| 6 | Hydrogels as Biomaterials Hydrogel Structure and Physical Chemistry Methods of Polymerization | |
| 7 | Hydrogels as Biomaterials (cont.) Theory of Hydrogel Swelling Physical Hydrogels
| Problem set 3 due Problem set 4 out |
| 8 | Hydrogels as Biomaterials (cont.) Polyelectrolyte Hydrogels Coacervates Polyelectrolyte Multi-layers | |
| 9 | Hydrogels as Biomaterials (cont.) Theory of Polyelectrolyte Gel Swelling | Problem set 4 due Problem set 5 out |
| 10 | Hydrogels as Biomaterials (cont.) Applications of Hydrogels: Molecular Imprinting Applications of Hydrogels: Glucose-sensitive Drug Delivery Kinetics of Drug Diffusion Through Hydrogels | |
| 11 | Engineering Biological Recognition of Biomaterials Biological Recognition in Vivo Protein-resistant and Cell-resistant Surfaces Engineering Recognition of Biomaterials: Adhesion and Migration | Problem set 5 due |
| Exam 1 | ||
| 12 | Engineering Biological Recognition of Biomaterials (cont.) Enzymatic Recognition of Biomaterials Cytokine Signaling from Biomaterials | |
| 13 | Engineering Biological Recognition of Biomaterials (cont.) Mimicking Cell-cell Contacts with Surfaces | Problem set 6 out |
| 14 | Bioceramics and Biocomposites Introduction to Biological Approaches to Biomineralization Interfacial Biomineralization | |
| 15 | Bioceramics and Biocomposites (cont.) Biological Control of Mineralization within Vesicles Biomimetic Syntheses: Microemulsion and Micellar Reactions Organic Templating of Inorganic Biomaterials: Natural and Synthetic Approaches | Problem set 6 due Problem set 7 out |
| 16 | Bioceramics and Biocomposites (cont.) Theory of Controlled Nucleation Bone Structure and Bone Biomimesis Biocomposites in Device Applications and Drug Delivery | |
| 17 | Molecular Devices Molecular Switches via Proteins and 'Smart' Polymers
Molecular Motors
| Problem set 7 due Problem set 8 out |
| 18 | Nanoparticle and Microparticle Biomolecule Drug Carriers Pro-drugs, Micelles, Liposomes, Polymerosomes, Nanoparticles, and Microparticles Delivery of Drugs to Tissues via Systemic Circulation Materials for Anti-Cancer Drug Delivery | |
| 19 | Nanoparticle and Microparticle Biomolecule Drug Carriers (cont.) Barriers to Systemic / Oral Delivery and Delivery of Molecules to Tissues 'Stealth' Particles
Experimental Function of Long-circulating Carriers and PEGylated Compounds | Problem set 8 due Take-home exam distributed |
| Focus Topic: Integrating Biological Knowledge Into Biomaterials Design For Vaccines | ||
| 20 | Basic Biology of Vaccination and Viral Infections Rudiments of Adaptive Immunity: The Basis of Vaccination Viral Infections | |
| 21 | Basic Biology of Vaccination and Viral Infections (cont.) Vaccination Against Viruses: Parallels between Immunization and Infection | |
| 22 | Drug Targeting and Intracellular Drug Delivery for Vaccines Targeting Nano-carriers and Micro-carriers to Specific Cell Types Chemistry of Antibodies for Targeting Pathways of Intracellular Transport | |
| 23 | Drug Targeting and Intracellular Drug Delivery for Vaccines (cont.) Mechanisms of Intracellular Delivery Mimicking Viral Entry Strategies | |
| 24 | DNA Vaccines Gene Therapy and DNA Immunization Mechanisms of DNA Vaccines | |
| 25 | DNA Vaccines (cont.) Delivery Systems for DNA Systemic vs. Local Delivery | Take-home exam due |