| 1 | Reaction models; simple kinetics & equilibria | Bob Sauer |
| 2 | Analyzing kinetic & equilibria experiments | |
| 3 | Free energy, entropy, enthalpy & cycles | |
| 4 | Forces, hydrophobic effect, chelate effect | |
| 5 | Molecular structure and dynamics | |
| 6 | Physical properties of proteins and nucleic acids | Tania Baker |
| 7 | Principles and practice of protein purification | |
| 8 | Principles and practice of protein purification (cont.) | |
| 9 | EXAM 1 | |
| 10 | Domain & subunit organization; molecular weight determination | Tania Baker |
| 11 | Macromolecular interactions: specificity, affinity and energetics | |
| 12 | Macromolecular interactions: specificity, affinity and energetics (cont.) | |
| 13 | Enzyme catalysis: kinetics | Frank Solomon |
| 14 | Mechanism of enzyme catalyzed reactions | |
| 15 | inhibition and intermediates | |
| 16 | Mechanism of enzyme catalyzed reactions: chemistry | |
| 17 | Mechanism of enzyme catalyzed reactions: partitioning & exchange | |
| 18 | Mechanism of enzyme catalyzed reactions: binding energy | |
| 19 | Specificity of catalysis: energetics and consequences | |
| 20 | Specificity of catalysis: energetics and consequences (cont.) | |
| 21 | EXAM 2 | |
| 22 | Coupled vectorial processes: making ATP | Frank Solomon |
| 23 | Coupled vectorial processes: pumps | |
| 24 | Coupled vectorial processes: OxPhos, morphology to enzymology | |
| 25 | Coupled vectorial processes: processivity | |
| 26 | Coupled vectorial processes: Motors; Polymers – origins & consequences of structural & thermodynamic polarity | |
| 27 | Coupled vectorial processes: motors; structural & thermodynamic polarity | |
| 28 | Coupled vectorial processes: protein folding | |
| 29 | Review Session | |
| 30 | FINAL EXAM | |