| LEC # | TOPICS | LECTURERS | READINGS |
|---|---|---|---|
| 1 | Early Earth/Microbial Evolution | Prof. Ed DeLong | Chapter 11 in Brock |
| 2 | Cell Structure/Function | Prof. Ed DeLong | Chapter 4 in Brock |
| 3 | Biological Energy Conservation | Prof. Ed DeLong | Chapters 5 and 17 in Brock |
| 4 | Microbial Growth | Prof. David Schauer | Chapter 6 in Brock |
| 5 | Metabolic Regulation | Prof. Ed DeLong | |
| 6 | Virology | Prof. David Schauer | Chapter 9 in Brock |
| 7 | Information Flow in Biological Systems | Prof. Ed DeLong | Chapter 10 in Brock |
| Midterm I | |||
| 8 | Regulation of Cell Activity | Prof. Ed DeLong | Chapter 8 in Brock |
| 9 | Genetic Exchange in Bacteria | Prof. Ed DeLong | |
| 10 | Experimental Evolution: Optimization of Metabolic Systems | Guest Lecturer, Prof. Christopher Marx from Harvard | Marx, Christopher J., Stephen J. Van Dien, and Mary E. Lidstrom. "Flux Analysis Uncovers Key Role of Functional Redundancy in Formaldehyde Metabolism." PLOS Biology 3 (2005): 244-253. (PDF) |
| 11 | Genomics I | Prof. Ed DeLong | Chapter 15 in Brock |
| 12 | Genomics II | Prof. Ed DeLong | Chapter 15 in Brock |
| 13 | Metabolic Diversity I | Prof. Ed DeLong | Chapter 17 in Brock |
| 14 | Metabolic Diversity II | Prof. Ed DeLong | Chapter 17 in Brock |
| 15 | Microbial Ecology | Prof. Ed DeLong | Chapter 19 in Brock |
| Midterm II | |||
| 16 | Microbial Growth Control | Prof. David Schauer | Chapter 20 in Brock |
| 17 | Microbe-host Interactions | Prof. David Schauer | Chapter 21 in Brock Backhed, Fredrik, et al. "Host-Bacterial Mutualism in the Human Intestine." Science 307 (2005): 1915-1920. |
| 18 | Immunology I | Megan McBee | Chapters 22 and 23 in Brock |
| 19 | Immunology II | Megan McBee | |
| 20 | Diagnostic Microbiology | Prof. David Schauer | Chapters 21 and 24 in Brock |
| 21 | Person-to-person Transmission | Prof. David Schauer | Chapter 25 in Brock |
| 22 | Epidemiology | Megan McBee | Chapter 26 in Brock |
| 23 | Animal- and Arthropod-transmitted Diseases | Prof. David Schauer | Chapter 27 in Brock |
| 24 | Review | Prof. David Schauer | Chapters 28 and 29 in Brock |
| Final Exam |
Table of Contents
Study Materials
Readings
 Help support MIT OpenCourseWare by shopping at Amazon.com! MIT OpenCourseWare offers direct links to Amazon.com to purchase the books cited in this course. Click on the Amazon logo to the left of any citation and purchase the book from Amazon.com, and MIT OpenCourseWare will receive up to 10% of all purchases you make. Your support will enable MIT to continue offering open access to MIT courses. |
Many of the readings come from the course textbook, "Brock": Madigan, Michael, and John Martinko. Brock Biology of Microorganisms. 11th ed. Upper Saddle River, NJ: Pearson Prentice Hall, 2005. ISBN: 9780131443297.
Other Readings
Backhed, Fredrik, et al. "Host-Bacterial Mutualism in the Human Intestine." Science 307 (2005): 1915-1920.
Berg, Howard. "Motile Behavior of Bacteria." Physics Today on the Web (January 2000).
Galan, Jorge E., and Hans Wolf-Watz. "Protein Delivery into Eukaryotic Cells by Type III Secretion Machines." Nature 444 (2006): 567-573.
Jetten, Mike S. M., et al. "Microbiology and Application of the Anaerobic Ammonium Oxidation (‘Anammox’) Process." Environmental Biotechnology 12 (2001): 283-288.
Lovley, Derek R. "Bug Juice: Harvesting Electricity with Microorganisms." Nature Reviews Microbiology 4 (2006): 497-508.
Marx, Christopher J., Stephen J. Van Dien, and Mary E. Lidstrom. "Flux Analysis Uncovers Key Role of Functional Redundancy in Formaldehyde Metabolism." PLOS Biology 3 (2005): 244-253. (PDF)
Moran, Nancy A., Fordon R. Plague, Jonas P. Sandstro, and Jennifer L. Wilcox. "A Genomic Perspective on Nutrient Provisioning by Bacterial Symbionts of Insects." PNAS 100 (2003): 14543-14548.
Nakabachi, Atsushi, et al. "The 160-Kilobase Genome of the Bacterial Endosymbiont Carsonella." Science 314 (2006): 267.
Pace, Norman R. "Time for a Change." Nature 441 (2006): 289.
Purcell, E. M. "Life at Low Reynolds Number." American Journal of Physics 45 (1977): 3-11.
Santiago, F. Elena, and Richard E. Lenski. "Evolution Experiments with Microorganisms: The Dynamics and Genetic Bases of Adaptation." Nature Reviews Genetics 4 (2003): 457-469.
Tamas, Ivica, et al. "50 Million Years of Genomic Stasis in Endosymbiotic Bacteria." Science 296 (2002): 2376-2379.
Wu, Dongying, et al. "Metabolic Complementarity and Genomics of the Dual Bacterial Symbiosis of Sharpshooters." PLOS Biology 4 (2006): 1079-1092. (PDF - 1.0 MB)