| LEC # | TOPICS |
|---|---|
| 1 | Course Introduction Model networks involved in signaling - Signals that start outside of the cell (role of the ECM) and trigger cascades inside the cell, ultimately affecting gene expression |
| 2 | Information flow in the reverse direction - from DNA to RNA to protein (the central dogma) Review of regulatory circuits and introduction to the concept of evolutionary genomics Key Issues: DNA replication and repair errors lead to mutations. Loss of mismatch repair leads to a hyper-Rec phenotype, which facilitates horizontal gene transfer (antibiotic resistance, etc.) |
| 3 | Decoding Information I (Transcription Regulation) |
| 4 | Modeling Macromolecular Structure I Individual Homework Assignments |
| 5 | Decoding Information II (Translation) |
| 6 | Modeling Macromolecular Structure II Students Present Homework |
| 7 | Roundtable Discussion |
| Examination 1 | |
| 8 | How to Write an NIH Grant Proposal |
| 9 | Analysis of the Interferon Network (The JAK/STAT System) |
| 10 | Analysis of the Interferon Network |
| 11 | Analysis of the Interferon Network (cont.) |
| 12 | Analysis of the Interferon Network (cont.) |
| 13 | Roundtable 1: Students Present Model Projects on Apoptosis |
| 14 | Chemotaxis I - How Salvage Pathways Supplement Core Biochemical Pathways The Che System Receptor Methylation as a Mechanism of Control of Chemotaxis |
| 15 | Chemotaxis II - How CheY(P) Signals to the Flagellar Motor Chemiosmotic Coupling Chemotaxis III. Proton Pumps |
| 16 | Introduction to the Extracellular Matrix Roundtable 2 Will be Delayed for a Few Weeks |
| 17 | Epithelial Cell Morphogenesis Signaling Hierarchy I |
| 18 | Epithelial Cell Morphogenesis Signaling Hierarchy II |
| 19 | Round Table Discussion |
| 20 | Epithelial Cell Morphogenesis Signaling Hierarchy III |
| Examination 2 | |
| 21 | Roundtable 3 |
| 22 | Changes in Lung Epithelium During Pathogenesis I |
| 23 | Changes in Lung Epithelium During Pathogenesis II |
| 24 | Network Example: Functional Glycomics |
| Final Papers Due |