| SES # | INSTRUCTORS | TOPICS | READINGS |
|---|---|---|---|
| L1 | FMW | Introduction - 20, 20.320, Biology, Mechanisms, and Modeling Protein Interactions | W&T. Chapter 2. |
| R1 | KA/SW/CR | Recitation 1 | |
| L2 | FMW | Protein Interactions II Thermodynamics of Monovalent Interactions | W&T. Chapter 2, 2.5.2. |
| L3 | FMW | Monovalent Interactions | W&T. Chapter 3. |
| R2 | Recitation 2 | ||
| L4 | FMW | Fractional Saturation | W&T. Chapter 3.1-3.2. |
| L5 | FMW | Measurement Techniques for Kd | |
| R3 | KA/SW/CR | Recitation 3 | |
| L6 | FMW | Perturbations to Monovalent Interactions | |
| L7 | FMW | Perturbations II - Solution Effects | |
| R4 | Recitation 4 | ||
| L8 | FMW | Multivalent Binding | W&T. Chapter 3.3. |
| L9 | FMW | Cooperativity | W&T. Chapter 3.3.2. |
| R5 | Recitation 5 | ||
| L10 | FMW | Avidity and Effective Concentration | W&T. Chapter 3.3.2. |
| R6 | CR/SW | Recitation 6 | |
| FMW | Exam 1 - Monovalent Binding, Measurement, Perturbations, Multivalent Binding, Cooperativity | ||
| L11 | FMW | Enzyme Kinetics I | |
| L12 | FMW | Enzyme Kinetics II | |
| R7 | Recitation 7 | ||
| R8 | Recitation 8 | ||
| L13 | DAL | Enzyme Inhibitors | |
| L14 | DAL | Integrating Pathways Into Networks | |
| R9 | Recitation 9 | ||
| L15 | DAL | Ligand-Receptor Interactions | |
| L16 | DAL | Endocytic Trafficking I | L&L. Chapter 3. |
| R10 | Recitation 10 | ||
| R11 | CR/SW | Recitation 11 | |
| DAL/FMW | Exam 2 - Avidity, Enzymes, and Networks | ||
| L17 | DAL | Endocytic Trafficking II | L&L. Chapter 6.1.3b. |
| L18 | DAL | Biomolecular Reactions in Context of Transport | |
| R12 | Recitation 12 | ||
| L19 | DAL | Fundamentals of Molecular Transport | |
| L20 | DAL | Reaction Terms and Approximations | |
| R13 | Recitation 13 | ||
| L21 | DAL | Macroscopic and Microscopic Effects of Diffusion | |
| L22 | DAL | Autocrine/Paracrine Cell-cell Communication | L&L. Chapter 6.1.3c. |
| R14 | Recitation 14 | ||
| L23 | DAL | Cell Population Dynamics I: Cell Growth, Death, Differentiation, and Product Synthesis | |
| L24 | DAL | Cell Population Dynamics II: Application to Tissues and Bioreactors | |
| DAL | Exam 3 - Test Accumulated Knowledge (Emphasis on Mechanisms Underlying Biomolecular Systems) |
Table of Contents
Study Materials
Readings
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Instructors
DAL: Prof. Douglas Lauffenburger
FMW: Prof. Forest White
KA: Kathyryn Armstrong
SW: Shan Wu
CR: Craig Rothman
Textbooks
[W&T] Tidor, Bruce, and K. Dane Wittrup. Biological Kinetics.
[L&L] Lauffenburger, Douglas A., and Jennifer Linderman. Models for Binding, Trafficking, and Signaling. New York, NY: Oxford University Press, 1996. ISBN: 9780195106633.