| Lec # | TOPICS | READINGS |
|---|---|---|
| 1 | Course Introduction Biomaterials Defined Structural Hierarchy in Materials and Biology | Whitesides, G. M., and A. P. Wong. "The Intersection of Biology and Materials Science." MRS Bulletin 31 (2006): 19-27. Ratner: pp. 1-26, Sections 2.1, 2.2, 2.9, and 2.10. |
| 2 | Biomaterials Surfaces: Physics Surface (vs. Bulk) Structure and Properties Surface Energy Adsorption, Segregation, and Reconstruction at Surfaces | Ratner: pp. 40-45, Section 1.5. |
| 3 | Biomaterials Surfaces: Chemistry Reactions at Surfaces: Chemisorption, Corrosion | Jacobs, J. J., J. L. Gilbert, and R. M. Urban. "Corrosion of Metal Orthopaedic Implants." Journal of Bone and Joint Surgery 80A (1998): 268-282. Ratner: Section 6.3. |
| 4 | Biomaterials Surfaces: Chemistry (cont.) Hydrolysis (Dr. Taniguchi) | Ratner: pp. 411-416, Section 2.7. Ikada, Y., and H. Tsuji. "Biodegradable Polyesters for Medical and Ecological Applications." Macromolecular Rapid Communications 21 (2000): 117-132. |
| 5 | Protein-Surface Interactions Proteins: Structure, Properties, Functions Protein Adsorption: Langmuir Model | Ratner: pp. 237-246. |
| 6 | Protein-Surface Interactions (cont.) Protein Adsorption: Complex Phenomena, Measurement | |
| 7 | Cell-Surface Interactions: Host Response to Biomaterials Cell Adhesion Mechanisms Coagulation Cascade | Ratner: Section 4.6. |
| 8 | Cell-Surface Interactions: Host Response to Biomaterials (cont.) Immune Response: Alternative Complement Activation | Ratner: Sections 3.4, 4.2, 4.3, and 4.4. |
| 9 | Surface Modification Methods Purposes Plasma Treatments Organic Coatings (Dr. Taniguchi) | Ratner: Sections 2.13, 2.14, 2.16, and 7.2. |
| Quiz 1 | ||
| 10 | Surface Modification Methods (cont.) Polymer Coatings Patterned Surfaces | |
| 11 | Surface Characterization In Vacuum: XPS/ESCA, AES, SIMS | Ratner: pp. 42-57 |
| 12 | Surface Characterization In situ Contact Angle, AFM | |
| 13 | Quantifying Cell Behavior Cell Cultures Cellular Assays: Adhesion, Migration, Proliferation | Handouts: Principles of Biochemistry, Receptors: Models for Binding, Trafficking, and Signaling. |
| 14 | Quantifying Cell Behavior (cont.) Cellular Assays: Differentiation, Function | |
| 15 | Statistical Analysis Error Sources, Distribution Functions, t- test | Ratner: Section 9.4. Handout: Experimentation: An Introduction to Measurement Theory. |
| 16 | Statistical Analysis (cont.) Fisher Test, Regression Methods | Marazuela, M. D., and M. C. Moreno-Bondi. "Fiber-optic Biosensors - An Overview." Analytical and Bioanalytical Chemistry 372 (2002): 664-682. |
| 17 | Biosensors and Diagnostic Devices Biological Elements Transduction Mechanisms Properties Examples: Fiber Optic Biosensors, Nanobarcodes | Ratner: Sections 7.17 and 7.18. |
| Quiz 2 | ||
| 18 | Drug Delivery: Controlled Release (Dr. Taniguchi) Chemically-controlled Devices | |
| 19 | Drug Delivery: Controlled Release (cont.) Diffusion-controlled, Membrane-based and Osmotic Devices | Ratner: Section 7.14. Duncan, Ruth. "The Dawning Era of Polymer Therapeutics." Nature Reviews Drug Discovery 2 (2003): 347-360. |
| 20 | Drug Delivery: Controlled Release (cont.) Methods: Transdermal, Colloidal Vehicles Mechanical Pumps | |
| 21 | Biomaterials for Organ Replacement Organ Replacement Therapies Mechanical Properties Bone Substitutes | Ratner: pp. 26-32, Sections 2.12 and 7.7. |
| 22 | Tissue Engineering Cell Types Approaches: In vitro, In vivo, Ex vivo/Cell Encapsulation Scaffolds: Design and Fabrication | Ratner: Chapter 8. |
| 23 | Tissue Engineering (cont.) Case Examples: Artificial Pancreas, Cartilage, Nerve Regeneration | |
| 24 | FDA Regulatory Issues and Course Evaluations | Ratner: Sections 10.1-10.4. |
| Final Exam |
Table of Contents
Study Materials
Readings
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Many assigned readings are from the course textbook:
Ratner, Buddy D., et al. Biomaterials Science: An Introduction to Materials in Medicine. 2nd ed. Burlington, MA: Academic Press, 2004. ISBN: 9780125824637.