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Text Yannas, I. V. Tissue and Organ Regeneration in Adults. New York, NY: Springer, 2001. ISBN: 9780387952147.
| I. Tissue Environment of the Implanted Biomaterial: Unit Cell Processes | | L1 | Survey of Clinical Cases of Biomaterials-Tissue Interactions | | Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm (PDF) | | L2 | Tissue Structures, Unit Cell Processes, and Integrins | | Giancotti, F. G., and E. Ruoslahti. "Integrin Signaling." Science 285 (13 Aug 1999): 1028-1032.
This paper presents the concept of integrin signaling.
Ruoslathi, E., and M. D. Pierschbacher. "New Perspectives in Cell Adhesion: RGD and Integrins." Science 238, no. 4826 (23 Oct 1987): 491-497.
This paper describes the discovery of an amino acid sequence that is a ligand for integrins.
Working/Operational Definitions (PDF)
Tissue Structure/Unit Cell Processes (PDF) | | L3 | Unit Cell Processes Comprising the Healing Response | | | | L4 | Irreversible Healing Behavior of the Extracellular Matrix (ECM) of Organs | Chapters 1-4 | | | L5 | Biochemistry of the ECM | | Extracellular Matrix Molecules (PDF) | | L6 | Scaffolds Based on ECM Analogs Used in Organ Synthesis | Chapter 8 | | | L7 | Organ Replacement by Induced Regeneration and Tissue Engineering | | | | L8 | Principles and Practice of Tissue Engineering | | | | E1 | Quiz 1 | | | | II. Physicochemical Interactions at the Surface of Biomaterials and Signaling within Tissue | | L9 | Characteristics of the Surfaces of Biomaterials | | Characteristics of the Surfaces of Biomaterials (PDF) | | L10 | Methodology for the Analysis of Surfaces | | Ratner, B. D. "Surface Properties of Biomaterials." In Biomaterials Science. Edited by B. D. Ratner, et. al. Burlington, MA: Academic Press, 1996. ISBN: 9780125824606.
Methodology for Chemical Analysis of Surfaces (PDF) | | L11 | Physicochemical Principles of Protein Adsorption on Solid Surfaces | | Andrade, J. D. "Principles of Protein Adsorption." In Surface and Interfacial Aspects of Biomedical Polymers. Vol. 2. Edited by J. D. Andrade. NY: Plenum Press, 1985.
Chinn, J. A., et. al. "Postadsorptive transitions in fibrinogen adsorbed to polyurethanes." Journal of Biomedical Materials Research 26 (1992): 757-778.
Rapoza, R. J., and T. A. Horbett. "Postadsorptive transitions in fibrinogen: Influence of polymer properties." Journal of Biomedical Materials Research 24 (1990): 1263-1287. | | L12 | Protein/Cell/Tissue-Biomaterials Interactions | | | | L13 | Linear vs. Cooperative Cell-Matrix Interactions | | | | L14 | Cell-Matrix Interactions During Spontaneous Healing | Chapter 9 | | | L15 | Contraction-Blocking Theory of Regeneration in Adults | Chapters 8 and 10 | | | E2 | Quiz 2 | | | | III. In Vivo and Clinical Case Studies | | L16 | Joints and Dental Tissues: Prosthetic Replacement | | Joints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon (PDF) | | L17 | Joints and Dental Tissues: Regeneration 1 | | | | L18 | Joints and Dental Tissues: Regeneration 2 | | | | L19 | Epithelialization (Epidermal Regeneration) and Endothelialization of Vascular Prostheses | | | | L20 | Rules for Synthesis of Tissues and Organs | Chapter 7 | | | L21 | In Vivo Synthesis of Skin | Chapter 5 | | | L22 | In Vivo Synthesis of Peripheral Nerves | Chapter 6 | | | L23 | In Vivo Synthesis of the Conjunctiva and of Kidney Tissue | Chapter 8 | | | E3 | Quiz 3 | | |
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