| SES # | TOPICS | READINGS |
|---|---|---|
| 3 | Discussion: Genome | Lindblad-Toh, K. et al. "Genome sequence, comparative analysis and haplotype structure of the domestic dog." Nature 438 (2005): 803-819. |
| 5 | Discussion: Cell Cycle Control | Malumbres, M., R. Sotillo, D. Santamaria, J. Galan, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid. "Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6." Cell 118 (2004): 493-504. |
| 7 | Discussion: Transcription Apparatus and Regulators | Spilianakis, C.G., Lalioti, M.D., Town, T., Lee, G.R., and Richard A. Flavell, R.A. "Interchromosomal associations between alternatively expressed loci." Nature 435 (2005): 637-645. |
| 9 | Discussion: Chromatin and Gene Expression I | Schmitt, S., M. Prestel, and R. Paro. "Intergenic transcription through a polycomb group response element counteracts silencing." Genes Dev 19 (2005): 697-708. |
| 11 | Discussion: Chromatin and Gene Expression II | Carrozza, M.J. et al. "Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription." Cell 123 (2005): 581-592. |
| 13 | Discussion: Genome Replication/Repair | Uhlmann, F., D. Wernic, M. A. Poupart, E. V. Koonin, and K. Nasmyth. "Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast." Cell 103 (2000): 375-386. |
| 15 | Discussion: Nuclear Structure, Import/Export | Gerber, A. P., D. Herschlag, and P. O. Brown. "Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast." PLos Biol 2 (2000): E79. |
| 17 | Discussion: DNA Modification/Epigenetics | Mager, J., Montgomery, N.D., Pardo-Manuel de Villena, F., and Magnuson, T. "Genome imprinting regulated by the mouse Polycomb group protein Eed." Nature Genetics 33 (2003): 502-507. |
| 19 | Discussion: Alternative Splicing/Polyadenylation | Han, K., G. Yeo, P. An, C. B. Burge, and P. J. Grabowski. "A combinatorial code for splicing silencing: UAGG and GGGG motifs." PLoS Biol 3 (2005): E158. |
| 21 | Discussion: Signal Transduction | Simone, C., Forcales, S.V., Hill, D.A., Imbalzano, A.N., Latella, L., and Puri, P.L. "p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci." Nature Genetics 36 (2004): 738-743. |
| 23 | Discussion: RNA Interference I - Silencing and microRNAs | Stark, A., J. Brennecke, N. Bushati, R. B. Russell, and S. M. Cohen. "Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3'UTR Evolution." Cell 123 (2005): 1133-1146. |
| 25 | Discussion: RNA Interference II - Transcription | Verdel, A., S. Jia, S. Gerber, T. Sugiyama, S. Gygi, S. I. Grewal, and D. Moazed. "RNAi-mediated targeting of heterochromatin by the RITS complex." Science 303 (2004): 672-676. Sugiyama, T., H. Cam, A. Verdel, D. Moazed, and S. I. Grewal. "RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production." Proc Natl Acad Sci 102 (2005): 152-157. |
| 26 | Course Review: Group Discussion |