| SES # | TOPICS | READINGS |
|---|---|---|
| 1 | Introduction | |
| 2 | Blastema formation | Reading 1 Whitehead, G. G., S. Makino, C. L. Lien, and M. T. Keating. "fgf20 is Essential for Initiating Zebrafish Fin Regeneration." Science 310 (2005): 1957-60. Reading 2 Yokoyama, H., H. Ogino, C. L. Stoick-Cooper, R. M. Grainger, and R. T. Moon. "Wnt/Beta-Catenin Signaling has an Essential Role in the Initiation of Limb Regeneration." Dev Biol 306 (2007): 170-8. |
| 3 | Progenitor cells I, stem cells | Reading 1 Bagna, J., E. Salo, and C. Auladell. "Regeneration and Pattern Formation in Planarians III. Evidence that Neoblasts are Totipotent Stem Cells and the Source of Blastema Cells." Development 107 (1989): 77-86. Reading 2 Reddien, P. W., N. J. Oviedo, J. R. Jennings, J. C. Jenkin, and A. Sánchez Alvarado. "SMEDWI-2 is a PIWI-like Protein that Regulates Planarian Stem Cells." Science 310 (2005): 1327-30. |
| 4 | Progenitor cells II, dedifferentiation | Reading 1 Lo, D. C., F. Allen, and J. P. Brockes. "Reversal of Muscle Differentiation During Urodele Limb Regeneration." PNAS 90 (1993): 7230-4. Reading 2 Morrison, J. I., S. Lööf, P. He, and A. Simon. "Salamander Limb Regeneration Involves the Activation of a Multipotent Skeletal Muscle Satellite Cell Population." J Cell Biol 172 (2006): 433-40. |
| 5 | Morphallaxis | Reading 1 Bode, H. R., and S. G. Cumming. "Head Regeneration and Polarity Reversal in Hydra Attenuata can Occur in the Absence of DNA Synthesis." Dev Gen Evol 194 (1984): 79-86. Reading 2 González-Estévez, C., D. A. Felix, A. A. Aboobaker, and E. Saló. "Gtdap-1 Promotes Autophagy and is Required for Planarian Remodeling During Regeneration and Starvation." PNAS 104 (2007): 13373-8. |
| 6 | Positional information I, regeneration polarity | Reading 1 Broun, M., L. Gee, B. Reinhardt, and H. R. Bode. "Formation of the Head Organizer in Hydra Involves the Canonical Wnt Pathway." Development 132 (2005): 2907-16. Reading 2 Gurley, K. A., J. C. Rink, and A. Sánchez Alvarado. "Beta-Catenin Defines Head versus Tail Identity During Planarian Regeneration and Homeostasis." Science 18 (2008): 323-7. |
| 7 | Positional information II, limb regeneration | Reading 1 Crawford, K., and D. L. Stocum. "Retinoic Acid Coordinately Proximalizes Regenerate Pattern and Blastema Differential Affinity in Axolotl Limbs." Development 102 (1988): 687-98. Reading 2 da Silva, S. M., P. B. Gates, and J. P. Brockes. "The Newt Ortholog of CD59 is Implicated in Proximodistal Identity During Amphibian Limb Regeneration." Dev Cell 4 (2002): 547-55. |
| 8 | Positional information III, intercalary regeneration | Reading 1 French, V., P. J. Bryant, and S. V. Bryant. "Pattern Regulation in Epimorphic Fields." Science 193 (1976): 969-81. Reading 2 Gibson, M. C., and G. Schubiger. "Hedgehog is Required for Activation of Engrailed During Regeneration of Fragmented Drosophila Imaginal Discs." Development 126 (1999): 1591-9. |
| 9 | Organ regeneration | Reading 1 Lepilina, A., A. N. Coon, K. Kikuchi, J. E. Holdway, R. W. Roberts, C. G. Burns, and K. D. Poss. "A Dynamic Epicardial Injury Response Supports Progenitor Cell Activity During Zebrafish Heart Regeneration." Cell 127 (2006): 607-19. Reading 2 Moolten, F. L., and N. L. Bucher. "Regeneration of Rat Liver: Transfer of Humoral Agent by Cross Circulation." Science 158 (1967): 272-4. |
| 10 | Adult stem cells | Reading 1 Gussoni, E., Y. Soneoka, C. D. Strickland, E. A. Buzney, M. K. Khan, A. F. Flint, L. M. Kunkel, and R. C. Mulligan. "Dystrophin Expression in the mdx Mouse Restored by Stem Cell Transplantation." Nature 401 (1999): 390-4. Reading 2 Wagers, A. J., R. I. Sherwood, J. L. Christensen, and I. L. Weissman. "Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells." Science 297 (2002): 2256-9. |
| 11 | Homeostasis I, progenitor cells | Reading 1 Dor, Y., J. Brown, O. I. Martinez, and D. A. Melton. "Adult Pancreatic Beta-Cells are Formed by Self-Duplication Rather than Stem-Cell Differentiation." Nature 429 (2004): 41-6. Reading 2 Micchelli, C. A., and N. Perrimon. "Evidence that Stem Cells Reside in the Adult Drosophila Midgut Epithelium." Nature 439 (2006): 475-9. |
| 12 | Homeostasis II, stem cell self-renewal and stem cell niche | Reading 1 Molofsky, A. V., R. Pardal, T. Iwashita, I. K. Park, M. F. Clarke, and S. J. Morrison. "Bmi-1 Dependence Distinguishes Neural Stem Cell Self-Renewal from Progenitor Proliferation." Nature 425 (2003): 962-7. Reading 2 Tumbar, T., G. Guasch, V. Greco, C. Blanpain, W. E. Lowry, M. Rendl, and E. Fuchs. "Defining the Epithelial Stem Cell Niche in Skin." Science 303 (2004): 359-63. |
| 13 | Regenerative medicine | Reading 1 Takahashi, K., and S. Yamanaka. "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors." Cell 126 (2006): 663-76. Reading 2 Cohn, R. D., et al. "Angiotensin II Type 1 Receptor Blockade Attenuates TGF-Beta—induced Failure of Muscle Regeneration in Multiple Myopathic States." Nat Med 13 (2007): 204-10. |
| 14 | Oral presentations |