| LEC # | TOPICS | LECTURERS | KEY DATES |
|---|---|---|---|
| I. Unit Cell Processes and Mechanics of Matrix Molecules and Tissues Structures | |||
| 1 | Clinical Examples of the Roles of Mechanical Forces in Tissues and Organs: The Working Paradigms | Prof. Spector | |
| 2 | Tissue Structures and Unit Cell Processes | Prof. Spector | |
| 3 | Cell-Matrix Interactions: Extracellular Matrix Molecules, Adhesion Proteins and Integrins | Prof. Spector | |
| 4 | Models for the Mechanical Behavior of Porous Scaffolds | Prof. L. Gibson | Homework 1 due |
| 5 | Structure-Properties Relationships for Tissues | Prof. Spector | |
| 6 | Mechanics of Selected Tissues | Prof. S. Socrate | |
| II. Mechanics of Cells: Effects of Exogenous Forces and Endogenous Force Generation | |||
| 7 | Effects of Exogenous Mechanical Forces on Cells | Prof. Spector | Homework 2 due |
| 8 | Response of Cells to Substrate Strain | Prof. Spector | |
| 9 | Endothelial Cell Response to Flow | Prof. C. F. Dewey | |
| 10 | Quiz 1 | ||
| 11 | Measuring Cell Contraction Cell Force Monitor | Brendan Harley | |
| 12 | Endogenous Mechanical Force Generation by Cells | Prof. Spector | |
| 13 | Models for Cell Contraction In Vitro and In Vivo | Prof. Spector | |
| 14 | Mechanical Coupling of Cells with Matrix | Prof. Yannas | |
| 15 | Cell-matrix Interactions During Wound Closure | Prof. Yannas | |
| 16 | Blockade of Contraction During Induced Organ Regeneration | Prof. Yannas | |
| 17 | Review | Prof. Spector | |
| 18 | Quiz 2 | ||
| III. Tissue Mechanics | |||
| 19 | Review of Principles of Linear Elastic Mechanics | Prof. Yannas | |
| 20 | Nonlinear Elasticity: Tendon and Skin | Prof. Yannas | |
| 21 | Linear Viscoelastic Behavior | Prof. Yannas | |
| 22 | Response of Articular Cartilage to Mechanical Loading | Prof. A. Grodzinsky | |
| 23 | Mechanical Behavior of Ligament, Meniscus and Intervertebral Disc | Prof. Spector | |
| 24 | Mechanical Behavior of Bone | Prof. Spector | Homework 3 due |
| 25 | Response of Bone to Mechanical Loading Review | Prof. Spector | |
| 26 | Quiz 3 | ||