Courses:

Seminar 1: The Alimentary Tract

Mucosal barrier

• General topics
• Tight junctions
• The glycocalyx
• Mucosa-Associated Lymphoid Tissue
• M-cells
  Molecular biology of colorectal carcinogenesis
  DNA mismatch repair genes and cancer
  Chemical, radiation, and drug-induced mucosal damage
  Microbial pathogenesis in the GI tract
  • Shigella
  • Sahnonella
  • E. Coli
  • H. pylori

Seminar 2: The Pancreatobiliary Tracts

Biology and physical chemistry of bile and bile salts
Structure and function of biological membranes
Mechanisms of hereditary and acquired pancreatic disease

• Acute and chronic pancreatitis
• Cystic Fibrosis
• Shwachman-Diamond syndrome
  Gallstone disease
• Genetics
• Biochemistry

Seminar 3: The Liver

Mechanisms of liver detoxification

• Microsomal enzymes
• Drug-induced liver disease
  Immunology of the liver
• Viral hepatitis
• Autoimmune liver disease
  Mechanisms of acute and chronic liver damage
• Alcoholic liver disease
• Fibrosis and cirrhosis
  Inherited/metabolic disorders of the liver
• Alphal-antitrypsin deficiency
• Tangier disease
• Glycogen storage disease
• Mucopolysaccharoidosis
• Lysosomal storage disease